Studie: Impfungen als Ursache von Epilepsie
(ht) Eine japanische Studie stellte bei 5,9 % der untersuchten Personen mit dem sog. "Rasmussen-Syndrom", einer hartnäckigen Form der Epilepsie, vorausgegangene Impfungen als (mit)verursachenden Faktor fest
Vaccination and infection as causative factors in Japanese patients withRasmussen syndrome: molecular mimicry and HLA class I.
Rasmussen syndrome is an intractable epilepsy with a putative causalrelation with cellular and humoral autoimmunity. Almost half of the patientshave some preceding causative factors, with infections found in 38.2%,vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In apatient with seizure onset after influenza A infections, cross-reaction of he patient's lymphocytes with GluR epsilon 2 and influenza vaccinecomponents was demonstrated by lymphocyte stimulation test. Database
analyses revealed that influenza A virus hemagglutinin and GluR epsilon 2 olecules contain peptides with the patient's HLA class I binding motif(HLA - A*0201). The relative risks of HLA class I genotypes for Rasmussen yndrome are 6.1 (A*2402), 6.4 (A*0201), 6.3 (A*2601) and 11.4 (B*4601). Therelative risks of HLA class I-A and B haplotypes are infinity (A*2601 + *5401), 21.1 (A*2402 + B*1501), 13.3 (A*2402 + B*4801) and 5.1 (A*2402 +B*5201). Some alleles and haplotypes of HLA class I may be the risk factors n Japanese patients. Cross-reactivity of cytotoxic T lymphocytes maycontribute to the processes leading from infection to the involvement of NS.
Quelle:
Clin Dev Immunol. 2006 Jun-Dec;13(2-4):381-7. PMID: 17162382
